Polyclonal Anti-CHRNA1

Rabbit IgG polyclonal antibody for Acetylcholine receptor subunit alpha (CHRNA1) detection. Tested with WB, IHC-P in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1203

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CHRNA1

References

1. Giraud, M.; Taubert, R.; Vandiedonck, C.; Ke, X.; Levi-Strauss, M.; Pagani, F.; Baralle, F. E.; Eymard, B.; Tranchant, C.; Gajdos, P.; Vincent, A.; Willcox, N.; Beeson, D.; Kyewski, B.; Garchon, H.-J. : An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature 448: 934-937, 2007. \n2. Noda, M.; Furutani, Y.; Takahashi, H.; Toyosato, M.; Tanabe, T.; Shimizu, S.; Kikyotani, S.; Kayano, T.; Hirose, T.; Inayama, S.; Numa, S. : Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor. Nature 305: 818-823, 1983.

Swiss Prot

P02708

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of human CHRNalpha1, identical to the related rat sequence, different from the related mouse sequence by one amino acid.

Scientific Background

CHRNA, also termed ACHRA, is mapped on 2q24-q32.This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subu gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule.