Polyclonal Anti-CYP2D6

Rabbit IgG polyclonal antibody for Cytochrome P450 2D6 (CYP2D6) detection. Tested with WB, IHC-P in Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1397

Size

100ug/vial

Applications

IHC, WB

Reactivities

Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CYP2D6

References

1. Entrez Gene: CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6\". \n2. Distlerath, L. M., Guengerich, F. P.Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.Proc. Nat. Acad. Sci.81: 7348-7352, 1984.\n3. Gonzalez, F. J., Matsunaga, T., Nagata, K., Meyer, U. A., Nebert, D. W., Pastewka, J., Kozak, C. A., Gillette, J., Gelboin, H. V., Hardwick, J. P.Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.DNA6: 149-161, 1987.\n

Swiss Prot

P10635

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence in the middle region of mouse CYP2D6, identical to the related rat sequence.

Scientific Background

Cytochrome P450 2D6 (CYP2D6) is one of the most important enzymes involved in the metabolism of xenobiotics in the body. It is a member of Cytochrome P450, family 2, subfamily D, polypeptide 6. Its gene is mapped to chromosome 22q13.1. It has got 497 amino acid proteins which shares 73% sequence identity with the rat protein. CYP2D6 is highly expressed in human liver. CYP2D6 is the major isozyme involved in the formation of N-hydroxyprocainamide, a metabolite potentially involved in the drug-induced lupus syndrome observed with procainamide