Polyclonal Anti-DUSP3

Rabbit IgG polyclonal antibody for Dual specificity protein phosphatase 3 (DUSP3) detection. Tested with WB in Human;Mouse;Rat. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1762

Size

100ug/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

DUSP3

References

Alonso, A., Rahmouni, S., Williams, S., van Stipdonk, M., Jaroszewski, L., Godzik, A., Abraham, R. \nT., Schoenberger, S. P., Mustelin, T. Tyrosine phosphorylation of VHR phosphatase by \nZAP-70. Nature Immun. 4: 44-48, 2003.\n2. Ishibashi, T., Bottaro, D. P., Chan, A., Miki, T., Aaronson, S. A. Expression cloning of a human \ndual-specificity phosphatase. Proc. Nat. Acad. Sci. 89: 12170-12174, 1992.\n3. Patterson, K. I., Brummer, T., O'Brien, P. M., Daly, R. J. Dual-specificity phosphatases: critical \nregulators with diverse cellular targets.Biochem. J. 418: 475-489, 2009.

Swiss Prot

P51452

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal\n of human DUSP3, identical to the related rat and \nmouse sequences.

Scientific Background

DUSP3(Dual-specificity phosphatase 3), also called VHR, is a member of the dual specificity protein \nphosphatase subfamily. DUSPs constitute a large heterogeneous subgroup of the type I cysteine-based \nprotein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate \nboth tyrosine and serine/threonine residues. DUSP3 contains the consensus DUSP C-terminal catalytic \ndomain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase \nphosphatase) class of DUSPs. The DUSP3 gene is mapped on 17q21.31. Confocal microscopy \ndemonstrated that phosphorylated VHR accumulated at the immune synapse between the T cell and \nthe antigen-presenting cell in the presence of antigen. Tyrosine phosphorylation of VHR affects \nprotein-protein interaction, subcellular location, or substrate targeting, given that tyr138 is located on \nthe opposite side of the VHR catalytic center.