| Catalogue number: |
PA1337 |
| Price: |
$200.00 |
| Reactivities: |
Human, Mouse, Rat |
| Applications: |
Western Blot |
| Size: |
100ug/vial |
| Gene: |
FAF1 |
| Swiss prot: |
Q9UNN5 |
| Form: |
Lyophilized |
| Format: |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: |
"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.
Avoid repeated freezing and thawing.
"
|
| Scientific background: |
Fas-associated factor-1 (FAF1) is a Fas-binding pro-apoptotic protein that is a component of the death-inducing signaling complex in Fas-mediated apoptosis. FAF1 is involved in negative regulation of NF-kappaB activation. In addition to the previously known function as a component of the Fas death-inducing signaling complex, i.e. NF-kappaB activity suppressor by cytoplasmic retention of NF-kappaB p65 via physical interaction. hFAF1 was expressed abundantly in testis, skeletal muscle, and heart as 2.8 kb mRNA. Polyclonal antibody against hFAF1 detected 74 kD protein, a deduced protein size from the ORF and 40 kD protein in some cell lines. |
| References: |
1. J Biol Chem. 2004 Jan 23;279(4):2544-9. Epub 2003 Nov 4.Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB.Research Center for Biomedicinal Resources and the Division of Life Science, PaiChai University, Daejeon 302-735, Korea.
2. 1\Ryu, S. W., Chae, S. K., Lee, K. J., Kim, E. Identification and characterization of human Fas associated factor 1, hFAF1. Biochem. Biophys. Res. Commun. 262: 388-394, 1999. |
| Additional info: |
A synthetic peptide corresponding to a sequence at the N-terminal of human FAF1, identical to the related mouse and rat sequences. |
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