Polyclonal Anti-FMO3

Rabbit IgG polyclonal antibody for Dimethylaniline monooxygenase [N-oxide-forming] 3 (FMO3) detection. Tested with WB in Human;Mouse;Rat. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1764

Size

100ug/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

FMO3

References

Akerman, B. R., Chow, L., Forrest, S., Youil, R., Cashman, J., Treacy, E. P. Mutations in the \nflavin-containing monoxygenase (sic) form 3 (FMO3) gene cause trimethylaminuria, fish odour \nsyndrome. (Abstract) Am. J. Hum. Genet. 61 (suppl.): A53 only, 1997.\n2. Cashman, J. R., Zhang, J. Interindividual differences of human flavin-containing monooxygenase 3: \ngenetic polymorphisms and functional variation. Drug Metab. Dispos. 30: 1043-1052, 2002.\n3. Dolphin, C. T., Janmohamed, A., Smith, R. L., Shephard, E. A., Phillips, I. R. Missense mutation in \nflavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nature Genet. 17: \n491-494, 1997.

Swiss Prot

P31513

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of \nhuman FMO3,different from the related rat sequence by one amino \nacid, and from the related mouse sequence by two amino acids.

Scientific Background

FMO3(Flavin-containing Monooxygenase 3) is an enzyme that in humans is encoded by \nthe FMO3 gene. The mammalian flavin-containing monooxygenases (FMO) represent a multigene \nfamily whose gene products are localized in the endoplasmic reticulum of many \ntissues. The FMO3 gene contains 1 noncoding and 8 coding exons. The FMO3 gene is mapped on \n1q24.3. Using quantitative RNase protection assays, FMO3 is present in low abundance in fetal liver \nand lung and in adult kidney and lung, and in much greater abundance in adult liver. By Western blot \nanalysis of human liver microsomal samples ranging from 8 weeks gestation to 18 years of age, FMO1 \nis the major fetal isoform and FMO3 is the major adult isoform. FMO3 was expressed at intermediate \nlevels until 11 years of age when a gender-independent increase in FMO3 expression was observed \nduring puberty. Sufferers of trimethylaminuria may display a reduced ability to metabolize substrates \nfor FMO3 such as nicotine. FMO3 metabolizes a number of drugs, including amphetamine, clozapine, \ndeprenyl, metamphetamine, tamoxifen, ethionamide, thiacetazone, and sulindac sulfide.