| Catalogue number: |
PA1037 |
| Price: |
$200.00 |
| Reactivities: |
Human, Mouse, Rat |
| Applications: |
Immunohistochemistry, Western Blot |
| Size: |
100ug/vial |
| Gene: |
GAP43 |
| Swiss prot: |
P17677 |
| Form: |
Lyophilized |
| Format: |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: |
"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.
Avoid repeated freezing and thawing.
"
|
| Scientific background: |
Growth Associated Protein-43(GAP-43), also known as nerve growth-related growth peptide GAP43, shares a high degree of homology between the sequence of the human gene and the rat gene. GAP-43 is considered a crucial component of an effective regenerative response in the nervous system. Somatic cell hybrids demonstrate localization of the GAP-43 gene to human chromosome 3 and to mouse chromosome 16. GAP-43 has been termed a "growth" or "plasticity" protein because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration. GAP-43 regulates growth of axons and modulates the formation of new connections. |
| References: |
1. Kosik, K. S.; Orecchio, L. D.; Bruns, G. A. P.; Benowitz, L. I.; MacDonald, G. P.; Cox, D. R.; Neve, R. L. : Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. Neuron 1: 127-132, 1988.
2. Strittmatter, S. M.; Fankhauser, C.; Huang, P. L.; Mashimo, H.; Fishman, M. C. : Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell 80: 445-452, 1995.
3. Chen, B.; Wang, J.-F.; Sun, X.; Young, L. T. : Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells. Biol. Psychiat. 53: 530-537, 2003. |
| Additional info: |
A synthetic peptide corresponding to a sequence at the C-terminal of the human GAP-43, different from the related mouse and rat sequences by one amino acid. |
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