Polyclonal Anti-GBP1

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Cheng, Y.-S. E., Patterson, C. E., Staeheli, P.Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.Molec. Cell. Biol. 11: 4717-4725, 1991.\n2. Olszewski, M. A., Gray, J., Vestal, D. J.In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.J. Interferon Cytokine Res. 26: 328-352, 2006.\n3. Tripal, P., Bauer, M., Naschberger, E., Mortinger, T., Hohenadl, C., Cornali, E., Thurau, M., Sturzl, M.Unique features of different members of the human guanylate-binding protein family.J. Interferon Cytokine Res. 27: 44-52, 2007\n

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Scientific Background

Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3 . The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3 , respectively. All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. The GBP1 gene to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG , TNF , or IL1B .