Polyclonal Anti-GJA3/connexin46

Rabbit IgG polyclonal antibody for Gap junction alpha-3 protein (GJA3) detection. Tested with WB, IHC-P, ICC in Human.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2144

Size

100ug/vial

Applications

ICC, IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

GJA3

References

1. Burdon, K. P., Wirth, M. G., Mackey, D. A., Russell-Eggitt, I. M., Craig, J. E., Elder, J. E., Dickinson, J. L., Sale, M. M. A novel mutation in the connexin 46 gene causes autosomal dominant congenital cataract with incomplete penetrance. J. Med. Genet. 41: e106, 2004. Note: Electronic Article. Errata: J. Med. Genet. 42: 288 only, 2004; J. Med. Genet. 45: 256 only, 2008.\n2. Chang, B., Wang, X., Hawes, N. L., Ojakian, R., Davisson, M. T., Lo, W.-K., Gong, X. A Gja8 (Cx50) point mutation causes an alteration of alpha-3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice. Hum. Molec. Genet. 11: 507-513, 2002.\n3. White, T. W. Unique and redundant connexin contributions to lens development.Science 295: 319-320, 2002.\n

Swiss Prot

Q9Y6H8

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human GJA3.

Scientific Background

Gap junction alpha-3 protein, also known as Connexin-46, is a protein that in humans is encoded by the GJA3 gene. This gene is mapped to 13q12.11. The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3).