Polyclonal Anti-GST pi

Rabbit IgG polyclonal antibody for Glutathione S-transferase P ( GSTP1) detection. Tested with WB in Human;Mouse. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1040

Size

100ug/vial

Applications

WB

Reactivities

Hum, Mouse

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

GSTP1

References

1. Morrow, C. S.; Cowan, K. H.; Goldsmith, M. E. : Structure of the human genomic glutathione S-transferase-pi gene. Gene 75: 3-11, 1989\n2. Islam, M. Q.; Platz, A.; Szpirer, J.; Szpirer, C.; Levan, G.; Mannervik, B. : Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi. Hum. Genet. 82: 338-342, 1989. \n3. Konohana, A.; Konohana, I.; Schroeder, W. T.; O'Brien, W. R.; Amagai, M.; Greer, J.; Shimizu, N.; Gammon, W. R.; Siciliano, M. J.; Duvic, M. :Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin. J. Invest. Derm. 95: 119-126, 1990.

Swiss Prot

P09211

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human GST pi, different from the related mouse sequence by two amino acids.

Scientific Background

Glutathione S-transferases pi, also known as GST3, present in all tissues and cells, with the exception of red cells, in which only erythrocyte GST (GSTe) is observed. The GST-pi gene has 7 exons and 6 introns contained within approximately 2.8 kilobases. The GST-pi gene is mapped to chromosome 11 .Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin. GSTP does not contribute in vivo to the formation of glutathione conjugates of acetaminophen but plays a novel and unexpected role in the toxicity of this compound.