| Catalogue number: |
PA2024 |
| Price: |
$200.00 |
| Reactivities: |
Human |
| Applications: |
Immunocytochemistry, Western Blot |
| Size: |
100ug/vial |
| Gene: |
EIF2AK1 |
| Swiss prot: |
Q9BQI3 |
| Form: |
Lyophilized |
| Format: |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: |
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: |
EIF2AK1 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1), also called HRI, is an enzyme that in humans is encoded by the EIF2AK1 gene. Hartz (2010) mapped the EIF2AK1 gene to chromosome 7p22.1 based on an alignment of the EIF2AK1 sequence with the genomic sequence. Chen and London (1995) reviewed the activation and control of rat and rabbit Hri. Hri functions as a dimer, and its activation involves autophosphorylation, which requires an invariant lysine in kinase domain II. Using cDNA arrays and Northern blot analysis, Hwang et al. (2000) found that HRI was downregulated in the majority of ovarian cancers examined compared with normal ovarian tissues. |
| References: |
1. Chen, J.-J., London, I. M. Regulation of protein synthesis by heme-regulated eIF-2-alpha kinase. Trends Biol. 20: 105-108, 1995.
2. Hartz, P. A. Personal Communication. Baltimore, Md. 10/25/2010.
3. Hwang, S.-Y., Kim, M.-K., Kim, J.-C. Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2-alpha kinase: down-regulated in epithelial ovarian cancers. Molec. Cells 10: 584-591, 2000.
|
| Additional info: |
A synthetic peptide corresponding to a sequence in the middle region of human EIF2AK1. |
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