Polyclonal Anti-HLA-DMB

Rabbit IgG polyclonal antibody for HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) detection. Tested with WB, IHC-P in Human. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1788

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

HLA-DMB

References

1. Fling, S. P., Arp, B., Pious, D. HLA-DMA and -DMB genes are both required for MHC class\nII/peptide complex formation in antigen-presenting cells. Nature 368: 554-558, 1994.\n2. Vogt AB, Kropshofer H (1999). \"HLA-DM - an endosomal and lysosomal chaperone for the immune \nsystem.\". Trends Biochem. Sci.24 (4): 150

Swiss Prot

P28068

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence in the middle region\nof human HLA-DMB.

Scientific Background

HLA-DMB(major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7,\nHLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein that in humans is \nencoded by the HLA-DMB gene. The HLA-DMB gene is mapped on 6p21.32. HLA-DMB belongs to the \nHLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) \nand a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays \na central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class \nII-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are \nexpressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains \n6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in \nthe pathway of class II antigen presentation.