Polyclonal Anti-HSPE1

Rabbit IgG polyclonal antibody for 10 kDa heat shock protein, mitochondrial (HSPE1) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1790

Size

100ug/vial

Applications

ICC, IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

HSPE1

References

1. Georgopoulos, C., Welch, W. J. Role of the major heat shock proteins as molecular \nchaperones. Annu. Rev. Cell Biol. 9: 601-634, 1993.\n2. Hansen, J. J., Bross, P., Westergaard, M., Nielsen, M. N., Eiberg, H., Borglum, A. D., Mogensen, J., \nKristiansen, K., Bolund, L., Gregersen, N. Genomic structure of the human mitochondrial chaperonin \ngenes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a \nbidirectional promoter. Hum. Genet. 112: 71-77, 2003. Note: Erratum: Hum. Genet. 112: 436 only, \n2003.\n3. Todd, M. J., Viitanen, P. V., Lorimer, G. H. Dynamics of the chaperonin ATPase cycle: implications for \nfacilitated protein folding. Science 265: 659-666, 1994.

Swiss Prot

P61604

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of \nhuman HSPE1, different from the related rat and mouse sequences by \none amino acid.

Scientific Background

HSPE1(heat shock 10kDa protein 1 (chaperonin 10)), also called CPN10, GROES, CHAPERONIN 10 \nHOMOLOG, cpn10 HOMOLOG or HSP10, is a protein that in humans is encoded by the HSPE1 gene. \nGroES is a heptameric ring of identical 10.4-kD subunits that binds to each end of GroEL to form a \nsymmetric, functional heterodimer. The HSP10 gene consists of 4 exons. The HSPE1 gene is mapped to \n2q33.1. The transcriptional activity of the promoter fragment in the HSP60 direction is approximately \ntwice that in the HSP10 direction under normal growth conditions; upon heat shock, promoter activity in \neither direction increased by a factor of approximately 12. Mutational drifts performed in vitro with 4 \ndifferent enzymes indicated the GroES overexpression doubled the number of accumulating mutations, \nand promoted the folding of enzyme variants carrying mutations in the protein core and/or mutations with \nhigher destabilizing effects.