Polyclonal Anti-IHH

Price

200.00 USD

Size

100?g/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Berman, D. M., Karhadkar, S. S., Maitra, A., Montes de Oca, R., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., Beachy, P. A. Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425: 846-851, 2003. \n2. Chung, U., Schipani, E., McMahon, A. P., Kronenberg, H. M. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J. Clin. Invest. 107: 295-304, 2001.\n3. Giordano, N., Gennari, L., Bruttini, M., Mari, F., Meloni, I., Baldi, C., Capoccia, S., Geraci, S., Merlotti, D., Amendola, A., Martini, G., Nuti, R., Gennari, C., Renieri, A. Mild brachydactyly type A1 maps to chromosome 2q35-q36 and is caused by a novel IHH mutation in a three generation family. J. Med. Genet. 40: 132-135, 2003.\n

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

Indian hedgehog, also known as IHH or HHG2 is a protein which in humans is encoded by the IHH gene. This gene encodes a member of the hedgehog family of secreted signaling molecules. IHH gene is mapped to 2q35. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth a differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.