Polyclonal Anti-IKBKG

Rabbit IgG polyclonal antibody for NF-kappa-B essential modulator (IKBKG) detection. Tested with WB in Mouse. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1551

Size

100ug/vial

Applications

WB

Reactivities

Mouse

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

IKBKG

References

1. Rothwarf, D. M., Zandi, E., Natoli, G., Karin, M.IKK-gamma is an essential regulatory subunit of the I-kappa-B kinase complex.Nature 395: 297-300, 1998.\n2. Yamaoka, S., Courtois, G., Bessia, C., Whiteside, S. T., Weil, R., Agou, F., Kirk, H. E., Kay, R. J., Israel, A.Complementation cloning of NEMO, a component of the I-kappa-B kinase complex essential for NF-kappa-B activation.Cell 93: 1231-1240, 1998.\n

Swiss Prot

O88522

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of mouse IKBKG, different from the relative rat sequence by three amino acids,

Scientific Background

IKBKG, (Inhibitor of kappa light polypeptide gene enhancer in B cells,kinase of ,gamma) is also know as NEMO . The IKK complex is composed of IKK-alpha, IKK-beta, and 2 other polypeptides of 50 and 52 kD which are differentially processed forms of a third subunit, IKK-gamma. The 419-amino acid IKK-gamma protein is composed of several potential coiled-coil motifs and a leucine zipper motif. NEMO interacted with IKK2 (IKK-beta), but not with IKK1 (IKK-alpha). IKK-gamma forms dimers and trimers and interacts preferentially with IKK-beta.