Polyclonal Anti-IL-8

Rabbit IgG polyclonal antibody for Interleukin-8 ( IL8) detection. Tested with WB, IHC-P in Human. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1353

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

IL8

References

1?Wolff B, Burns AR, Middleton J, Rot A (November 1998). \"Endothelial cell \"memory\" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies\". \n2?Utgaard JO, Jahnsen FL, Bakka A, Brandtzaeg P, Haraldsen G (November 1998). \"Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells\". \n3? Modi WS, Dean M, Seuanez HN, Mukaida N, Matsushima K, O'Brien SJ (January 1990). \"Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily\". \n4?\"Entrez Gene: IL8 interleukin 8\". \n5? K

Swiss Prot

P10145

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human IL8.

Scientific Background

Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. Interleukin-8 (IL8) is a member of the CXC chemokine family (Hull et al., 2001). IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. The genes for IL8 have been co-localized on a 335-kb genomic fragment.