Polyclonal Anti-ITGB2

Rabbit IgG polyclonal antibody for Integrin beta-2 (ITGB2) detection. Tested with WB, IHC-P in Human. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1124

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

ITGB2

References

1. Taylor, G. M.; Williams, A.; D'Souza, S. W.; Fergusson, W. D.; Donnai, D.; Fennell, J.; Harris, R. : The expression of CD18 is increased on trisomy 21 (Down syndrome) lymphoblastoid cells. Clin. Exp. Immun. 71: 324-328, 1988.\n2. Weitzman, J. B.; Wells, C. E.; Wright, A. H.; Clark, P. A.; Law, S. K. A. : The gene organisation of the human beta-2 integrin subunit (CD18). FEBS Lett. 294: 97-103, 1991.\n3. McDowall, A.; Inwald, D.; Leitinger, B.; Jones, A.; Liesner, R.; Klein, N.; Hogg, N. : A novel form of integrin dysfunction involving beta-1, beta-2, and beta-3 integrins. J. Clin. Invest. 111: 51-60, 2003.

Swiss Prot

P05107

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of human Integrin beta2, different from the related mouse sequence by five amino acids.

Scientific Background

The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The 3 alpha integrin chains associated individually with the beta-2 chain as a heterodimer have gene designations of ITGAL, ITGAM, and ITGAX, and leukocyte antigen designations of CD11A, CD11B, and CD11C, respectively.The expression of CD18 was increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21.The ITGB2 gene spans approximately 40 kb and contains 16 exons and all exon/intron boundaries conform to the GT/AG splicing consensus. Furthermore,ITGB2 was constitutively clustered. Although it was expressed on the cell surface at normal levels and was capable of function following extracellular stimulation, it could not be activated via the