Polyclonal Anti-KLK6

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Anisowicz, A., Sotiropoulou, G., Stenman, G., Mok, S. C., Sager, R. A novel protease homolog \ndifferentially expressed in breast and ovarian cancer. Molec. Med. 2: 624-636, 1996.\n2. Elliott, M. B., Irwin, D. M., Diamandis, E. P. In silico identification and Bayesian phylogenetic \nanalysis of multiple new mammalian kallikrein gene families. Genomics 88: 591-599, 2006.\n3. Iwata, A., Maruyama, M., Akagi, T., Hashikawa, T., Kanazawa, I., Tsuji, S., Nukina, \nN. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of \nsynucleinopathies.

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or \nPRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen \nkallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated \nby steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several \nprimary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in \nany metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the \nenzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, \nsuggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was \nreleased from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein \nspecies. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the \npathogenesis of synucleinopathies.