Quick Search
Products Polyclonal Anti-LALBA
| Catalogue number: | PA1708 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | LALBA |
| Swiss prot: | P00709 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | LALBA(lactalbumin, alpha or alpha-lactalbumin) is a protein that in humans is encoded by the LALBA gene. The LALBA gene is mapped on 12q13.11. alpha-Lactalbumin is an important whey protein in cow's milk (~1 g/l), and is also present in the milk of many other mammalian species. In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose. alpha-Lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta-1, 4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transferring galactose moieties to glucose. As a multimer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of human alpha-lactalbumin that may form in acidic environments such as the stomach, called HAMLET, probably induces apoptosis in tumor and immature cells. |
| References: | 1.Bounous, G., Kongshavn, P. A. L., Taveroff, A., Gold, P. Evolutionary traits in human milk proteins. Med. Hypotheses 27: 133-140, 1988. 2.Davies, M. S., West, L. F., Davis, M. B., Povey, S., Craig, R. K. The gene for human alpha-lactalbumin is assigned to chromosome 12q13. Ann. Hum. Genet. 51: 183-188, 1987. 3.Hakansson, A., Zhivotovsky, B., Orrenius, S., Sabharwal, H., Svanborg, C. Apoptosis induced by a human milk protein. Proc. Nat. Acad. Sci. 92: 8064-8068, 1995. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of human LALBA. |
Get the Best Promotions
