Polyclonal Anti-LASP1

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Schreiber, V., Masson, R., Linares, J. L., Mattei, M. G., Tomasetto, C., Rio, M. C.Chromosomal \nassignment and expression pattern of the murine Lasp-1 gene.Gene 207: 171-175, 1998.\n2. Tomasetto, C., Moog-Lutz, C., Regnier, C. H., Schreiber, V., Basset, P., Rio, M.-C.Lasp-1 (MLN 50) \ndefines a new LIM protein subfamily characterized by the association of LIM and SH3 \ndomains.FEBS Lett. 373: 245-249, 1995.\n3. Tomasetto, C., Regnier, C., Moog-Lutz, C., Mattei, M. G., Chenard, M. P., Lidereau, R., Basset, P., \nRio, M. C.Identification of four novel human genes amplified and overexpressed in breast \ncarcinoma and localized to the q11-q21.3 region of chromosome 17.Genomics 28: 367-376, 1995.

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

LASP1(LIM and SH3 domain protein 1), also known as LASP1, is a protein that in humans is encoded by \nthe LASP1 gene. This gene encodes a member of a LIM protein subfamily which is characterized by a \nLIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and \npossibly in cytoskeletal organization. LASP1 has been shown to interact with Zyxin. Tomasetto et al. \n(1995) mapped the LASP1 gene to chromosome 17q11-q21.3 by radioactive in situ hybridization.\nNorthern blot analysis revealed that LASP1 mRNA was expressed at a basal level in all normal tissues \nexamined and overexpressed in 8% of primary breast cancers. In most of these cancers, LASP1 and \nERBB2 were simultaneously overexpressed.