Polyclonal Anti-LAT

Rabbit IgG polyclonal antibody for Linker for activation of T-cells family member 1 (LAT) detection. Tested with WB, IHC-P, ICC in Human.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2161

Size

100?g/vial

Applications

ICC, IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

LAT

References

1. Hundt, M., Tabata, H., Jeon, M.-S., Hayashi, K., Tanaka, Y., Krishna, R., De Giorgio, L., Liu, Y.-C., Fukata, M., Altman, A. Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity 24: 513-522, 2006.\n2. Nunez-Cruz, S., Aguado, E., Richelme, S., Chetaille, B., Mura, A.-M., Richelme, M., Pouyet, L., Jouvin-Marche, E., Xerri, L., Malissen, B., Malissen, M. LAT regulates gamma-delta T cell homeostasis and differentiation. Nature Immun. 4: 999-1008, 2003.\n

Swiss Prot

O43561

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human LAT, different from the related mouse and rat sequences by six amino acids.

Scientific Background

Linker for activation of T cells, also known as LAT, is a protein which in humans is encoded by the LAT gene. This gene is mapped to 16p11.2. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.