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Products Polyclonal Anti-LEPR
| Catalogue number: | PA1891 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | LEPR |
| Swiss prot: | P48357 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | LEPR(Leptin receptor) also known as LEP-R, OBR, is a protein that in humans is encoded by the LEPR gene. The leptin hormone regulates adipose-tissue mass through hypothalamus effects on fullness and energy use. It acts through the leptin receptor (LEP-R), a single-transmembrane-domain receptor of the cytokine receptor family. By genetic mapping, Tartaglia et al. (1995) demonstrated that the Obr gene is located on mouse chromosome 4, in a 5.1-cM interval that contains the well-characterized recessive obesity mutation, diabetes (db). Chung et al. (1996) developed a genetic map of 1p in the region of the OBR gene. They mapped the OBR gene physically by radiation hybrid mapping and placed it on a contig composed of 10 adjacent YACs and 5 P1 artificial chromosomes (PACs). The location of the human homolog of Obr was predicted to be on 1p based on conserved linkage of most of the telomeric half of mouse chromosome 4 with human 1p. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295. |
| References: | 1. Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K. J., Breitbart, R. E., Duyk, G. M., Tepper, R. I., Morgenstern, J. P.Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.Cell 84: 491-495, 1996. 2. Park, K. S., Shin, H. D., Park, B. L., Cheong, H. S., Cho, Y. M., Lee, H. K., Lee, J.-Y., Lee, J.-K., Oh, B., Kimm, K.Polymorphisms in the leptin receptor (LEPR)--putative association with obesity and T2DM.J. Hum. Genet. 51: 85-91, 2006. 3. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Woolf, E. A., Monroe, C. A., Tepper, R. I.Identification and expression cloning of a leptin receptor, OB-R.Cell 83: 1263-1271, 1995. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human LEPR, different from the related mouse and rat sequences by two amino acids. |
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