Polyclonal Anti-Lipocalin-1

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Baumgartner, M., Holzfeind, P., Redl, B. Assignment of the gene for human tear prealbumin (LCN1), a member of the lipocalin superfamily, to chromosome 8q24. Cytogenet. Cell Genet. 65: 101-103, 1994.\n2. Blaker, M., Kock, K., Ahlers, C., Buck, F., Schmale, H. Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands. Biochim. Biophys. Acta 1172: 131-137, 1993\n3. Glasgow BJ, Abduragimov AR, Gasymov OK, Yusifov TN (2003). \"Tear lipocalin: structure, function and molecular mechanisms of action\". Adv. Exp. Med. Biol. 506 (Pt A): 555

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

Lipocalin-1(LCN1), also known as PREALBUMIN, TEAR or VEGP, is a protein that in humans is encoded by the LCN1 gene. Lipocalin-1 is a member of the lipocalin family of small secretory proteins, which is mapped on 9q34.3. Lipocalin-1 is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. It may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. LCN1 inhibits the cysteine-protease papain in vitro, similar to cystatins. And LCN1 plays a role in the nonimmunologic defense and in the control of inflammatory processes in oral and ocular tissues. The investigations presented the first clear evidence that LCN1 is induced in infection or inflammation and supported the idea that this lipocalin functions as a physiologic protection factor of epithelia in vivo.