Polyclonal Anti-MAPT

Rabbit IgG polyclonal antibody for Microtubule-associated protein tau (MAPT) detection. Tested with WB in Human. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1482

Size

100ug/vial

Applications

WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

MAPT

References

1. Andreadis, A., Brown, W. M., Kosik, K. S.Structure and novel exons of the human tau gene.Biochemistry 31: 10626-10633, 1992.\n2. Donlon, T. A., Harris, P., Neve, R. L.Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21. (Abstract)Cytogenet. Cell Genet. 46: 607, 1987.\n3. Rademakers, R., Cruts, M., van Broeckhoven, C.The role of tau (MAPT) in frontotemporal dementia and related tauopathies.Hum. Mutat. 24: 277-295, 2004.\n

Swiss Prot

P10636

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of human MAPT, different from the related mouse and rat sequence by three amino acids.

Scientific Background

MAPT, Microtubule-associated protein tau, appears to be enriched in axons. The MAPT gene is assigned to chromosome 17 by hybridization of a cDNA clone to flow-sorted and spot-blotted chromosomes and to 17q21 by in situ hybridization, containing 16 exons. The tau proteins are the product of alternative splicingfrom a single gene that in humans is designated MAPT. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons in the central nervous system and are less common elsewhere. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.