| Catalogue number: |
PA1058-1 |
| Price: |
$200.00 |
| Reactivities: |
Human, Mouse, Rat |
| Applications: |
Immunohistochemistry, Western Blot |
| Size: |
100ug/vial |
| Gene: |
GRIN2A |
| Swiss prot: |
Q12879 |
| Form: |
Lyophilized |
| Format: |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: |
"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.
Avoid repeated freezing and thawing.
"
|
| Scientific background: |
N-methyl-D-aspartate receptor channel, subunit epsilon-1(NMDAR2A),, also known as GRIN2A, mapped to 16p13.2. NMDA glutamate receptors mediate calcium ion accumulation in central myelin in response to chemical ischemia in vitro. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. |
| References: |
1. Kalsi, G.; Whiting, P.; Le Bourdelles, B.; Callen, D.; Barnard, E. A.; Gurling, H. : Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. Genomics 47: 423-425, 1998.
2. Micu, I.; Jiang, Q.; Coderre, E.; Ridsdale, A.; Zhang, L.; Woulfe, J.; Yin, X.; Trapp, B. D.; McRory, J. E.; Rehak, R.; Zamponi, G. W.; Wang, W.; Stys, P. K. : NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 439: 988-992, 2006. |
| Additional info: |
A synthetic peptide corresponding to a sequence at the C-terminal of human NMDAR2A, different from the related mouse sequence by three amino acids, and from the related rat sequences by four amino acids. |
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