Polyclonal Anti-OPCML

Rabbit IgG polyclonal antibody for Opioid-binding protein/cell adhesion molecule (OPCML) detection. Tested with WB, IHC-P in Human;Mouse;Rat. \n

Prices direct from BOSTER IMMUNOLEADER

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1131

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

OPCML

References

1. Sellar, G. C.; Watt, K. P.; Rabiasz, G. J.; Stronach, E. A.; Li, L.; Miller, E. P.; Massie, C. E.; Miller, J.; Contreras-Moreira, B.; Scott, D.; Brown, I.; Williams, A. R.; Bates, P. A.; Smyth, J. F.; Gabra, H. : OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Nature Genet. 34: 337-343, 2003.\n2. Shark, K. B.; Lee, N. M. : Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM). Gene 155: 213-217, 1995.

Swiss Prot

Q14982

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human OPCML, identical to the related rat and mouse sequence.

Scientific Background

Opioid-binding protein/cell adhesion molecule-like (OPCML), (also called opioid-binding cell adhesion molecule (OBCAM)). OPCML is a member of the IgLON family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules, as an excellent candidate for the 11q25 ovarian cancer TSG in EOC. The OPCML gene comprises 7 exons, spans approximately 600 kb, and is transcribed from telomere to centromere . And due to the lack of transmembrane domains necessary for signal transduction, it is improbable that OBCAM acts independently as an opioid receptor; more likely, it plays an important accessory role in opioid receptor function.