| Catalogue number: |
PA1893 |
| Price: |
$200.00 |
| Reactivities: |
Rat |
| Applications: |
Immunohistochemistry, Immunohistochemistry - frozen, Western Blot |
| Size: |
100ug/vial |
| Gene: |
PECAM1 |
| Swiss prot: |
Q3SWT0 |
| Form: |
Lyophilized |
| Format: |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: |
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: |
PECAM-1(Platelet endothelial cell adhesion molecule), also known as cluster of differentiation 31 (CD31) is a protein that in human is encoded by the PECAM1 gene found on chromosome 17. PECAM1 is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. Using a PCR-based analysis of somatic cell hybrids, Gumina et al. (1996) mapped PECAM1 to chromosome 17 in the region 17q23-qter. By fluorescence in situ hybridization, they assigned the PECAM1 locus specifically to 17q23. Several adhesion molecules expressed on platelets and endothelium also localized to 17q. Xie and Muller (1996) mapped the Pecam1 gene to mouse chromosome 6, region F3-G1, by fluorescence in situ hybridization. PECAM-1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions, and PECAM-1 plays a key role in removing aged neutrophils from the body. |
| References: |
1. Gumina, R. J., Kirschbaum, N. E., Rao, P. N., vanTuinen, P., Newman, P. J.The human PECAM1 gene maps to 17q23.Genomics 34: 229-232, 1996.
2. Newman, P. J., Berndt, M. C., Gorski, J., White, G. C., II, Lyman, S., Paddock, C., Muller, W. A.PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.Science 247: 1219-1222, 1990.
3. Xie, Y., Muller, W. A.Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1.Genomics 37: 226-228, 1996.
|
| Additional info: |
A synthetic peptide corresponding to a sequence at the C-terminal of rat PECAM-1. |
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