Polyclonal Anti-PPIB

Rabbit IgG polyclonal antibody for Peptidyl-prolyl cis-trans isomerase B (PPIB) detection. Tested with WB in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1448

Size

100ug/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

PPIB

References

1. Peddada, L. B., McPherson, J. D., Law, R., Wasmuth, J. J., Youderian, P., Deans, R. J.Somatic cell mapping of the human Cyclophilin B gene (PPIB) to chromosome 15.Cytogenet. Cell Genet. 60: 219-221, 1992.\n2. Price, E. R., Zydowsky, L. D., Jin, M., Baker, C. H., McKeon, F. D., Walsh, C. T.Human Cyclophilin B: a second Cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.Proc. Nat. Acad. Sci. 88: 1903-1907, 1991.\n3. Watashi, K., Ishii, N., Hijikata, M., Inoue, D., Murata, T., Miyanari, Y., Shimotohno, K.Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Molec. Cell 19: 111-122, 2005.\n

Swiss Prot

P23284

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence in the middle region of human PPIB, identical to the related mouse and rat sequence.

Scientific Background

Cyclophilin B, PPIB, Peptidyl-prolyl cis-trans isomerase B, is an enzyme that in humans is encoded by the PPIB gene. Cyclophilins, such as Cyclophilin B, bind the immunosuppressive drug cyclosporin A (CsA) with high affinity. Somatic cell mapping of the human Cyclophilin B gene (PPIB) to chromosome 15. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Cyclophilin B interacts with HCV RNA polymerase NS5B to directly stimulate its RNA binding activity.