Polyclonal Anti-Presenilin-2

Rabbit IgG polyclonal antibody for Presenilin-2 ( PSEN2) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1358

Size

100ug/vial

Applications

IHC, IHC-Fr, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

PSEN2

References

1.Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD (September 1995). \"A familial Alzheimer's disease locus on chromosome 1\". \n2.Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). \"Novel MITF targets identified using a two-step DNA microarray strategy\".

Swiss Prot

P49810

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of human Presenilin-2, different from the related mouse and rat sequences by two amino acids.

Scientific Background

Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene.[1]Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.[2]