| Scientific background: |
RBL2(Retinoblastoma-like protein 2) is a protein that in humans is encoded by the RBL2 gene. It is also known as Retionblastoma-related gene (RB2), P130. Yeung et al. (1993) mapped the RBL2 gene to human chromosome 16q12.2 and rat chromosome 19, using fluorescence in situ hybridization and somatic hybrid cell analysis, respectively. Based on known syntenic relationships among human, rat and mouse, the data suggested that the mouse homolog resides on chromosome 8. Deletions of chromosome 16q have been found in several human neoplasms, including breast, ovarian, hepatic, and prostate cancers, which supports the involvement of RB2 in human cancer as a tumor suppressor gene. Kong et al. (2006)found that RBL2 and RINT1 were essential for telomere length control in human fibroblasts, with loss of either protein leading to longer telomeres. Williams et al. (2006)found that mouse fibroblasts lacking Rb were less susceptible to an oncogenic HRAS allele than wildtype cells. In contrast, p107 (RBL1;) -/- and p130 -/- fibroblasts were more susceptible to HRAS-mediated transformation than wildtype cells. |
| References: |
1. Kong, L.-J., Meloni, A. R., Nevins, J. R.The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.Molec. Cell 22: 63-71, 2006.
2. Williams, J. P., Stewart, T., Li, B., Mulloy, R., Dimova, D., Classon, M.The retinoblastoma protein is required for Ras-induced oncogenic transformation.Molec. Cell. Biol. 26: 1170-1182, 2006.
3. Yeung, R. S., Bell, D. W., Testa, J. R., Mayol, X., Baldi, A., Grana, X., Klinga-Levan, K., Knudson, A. G., Giordano, A.The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19.Oncogene 8: 3465-3468, 1993.
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