Polyclonal Anti-SLC12A2

Rabbit IgG polyclonal antibody for Solute carrier family 12 member 2 (SLC12A2) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2169

Size

100?g/vial

Applications

IHC, IHC-Fr, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

SLC12A2

References

1. Dzhala, V. I., Talos, D. M., Sdrulla, D. A., Brumback, A. C., Mathews, G. C., Benke, T. A., Delpire, E., Jensen, F. E., Staley, K. J. NKCC1 transporter facilitates seizures in the developing brain. Nature Med. 11: 1205-1213, 2005.\n2. Nguyen, M., Pace, A. J., Koller, B. H. Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia. J. Exp. Med. 204: 1383-1393, 2007.\n

Swiss Prot

P55011

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of human SLC12A2, identical to the related mouse and rat sequences.

Scientific Background

Solute carrier family 12 (sodium/potassium/chloride transporters), member 2, also known as NKCC1, is widely distributed throughout the body, especially in organs that secrete fluids, called exocrine glands. By fluorescence in situ hybridization, this gene is mapped to chromosome 5q23.3. The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.