Polyclonal Anti-SLC7A5

Rabbit IgG polyclonal antibody for Large neutral amino acids transporter small subunit 1 (SLC7A5) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2187

Size

100?g/vial

Applications

ICC, IHC, IHC-Fr, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

SLC7A5

References

1. Gaugitsch, H. W., Prieschl, E. E., Kalthoff, F., Huber, N. E., Baumruker, T. A novel transiently expressed, integral membrane protein linked to cell activation: molecular cloning via the rapid degradation signal AUUUA. J. Biol. Chem 267: 11267-11273, 1992.\n2. Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, P. J., Loffing, J., Shoemaker, C. B., Verrey, F. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature 395: 288-291, 1998.\n

Swiss Prot

Q01650

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC7A5, different from the related rat and mouse sequences by one amino acid.

Scientific Background

Solute carrier family 7 member 5, also known as Large neutral amino acids transporter small subunit 1 or SLC7A5 is a protein that in humans is encodes by the SLC7A5 gene. This gene is mapped to 16q24.2. This gene acts as an amino acid exchanger. It involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. This gene plays a role in neuronal cell proliferation (neurogenesis) in brain. It involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity.