Polyclonal Anti-SMAD7

Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 7 (SMAD7) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1954

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

SMAD7

References

1. Lallemand, F., Mazars, A., Prunier, C., Bertrand, F., Kornprost, M., Gallea, S., Roman-Roman, S., Cherqui, G., Atfi, A. Smad7 inhibits the survival nuclear factor kappa-B and potentiates apoptosis in epithelial cells. Oncogene 20: 879-884, 2001.\n2. Roijer, E., Moren, A., ten Dijke, P., Stenman, G. Assignment of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 81: 189-190, 1998. \n3. Topper, J. N., Cai, J., Qiu, Y., Anderson, K. R., Xu, Y.-Y., Deeds, J. D., Feeley, R., Gimeno, C. J., Woolf, E. A., Tayber, O., Mays, G. G., Sampson, B. A., Schoen, F. J., Gimbrone, M. A., Jr., Falb, D. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Nat. Acad. Sci. 94: 9314-9319, 1997.\n

Swiss Prot

O15105

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human SMAD7, identical to the related rat and mouse sequences.

Scientific Background

SMAD7(Mother against decapentaplegic drosophila homolog of 7), also known as MADH7 or SMA- AND MAD-RELATED PROTEIN 7, is a protein that in humans is encoded by the SMAD7 gene. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of ligands. By somatic cell hybrid analysis, Topper et al. (1997) mapped the MADH7 gene to human chromosome 18. Topper et al. (1997) demonstrated that MADH7 and MADH6 could form complexes in endothelial cells. MADH7 was induced in cultured vascular endothelium by fluid mechanical forces and was capable of modulating endothelial gene expression in response to both humoral and biomechanical stimuli in vitro. By FISH, Roijer et al. (1998) refined the localization to 18q21.1. Lallemand et al. (2001) showed that cells stably expressing SMAD7 had increased susceptibility to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion.