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Polyclonal Anti-SPTLC1

Cat no: PA1777

Polyclonal Anti-SPTLC1

Rabbit IgG polyclonal antibody for Serine palmitoyltransferase 1 (SPTLC1) detection. Tested with WB, IHC-P in Human. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1777

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

SPTLC1

References

1. Dawkins, J. L., Hulme, D. J., Brahmbhatt, S. B., Auer-Grumbach, M., Nicholson, G. A.Mutations in \nSPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary \nsensory neuropathy type I.Nature Genet. 27: 309-312, 2001.\n2. McCampbell, A., Truong, D., Broom, D. C., Allchorne, A., Gable, K., Cutler, R. G., Mattson, M. P., \nWoolf, C. J., Frosch, M. P., Harmon, J. M., Dunn, T. M., Brown, R. H., Jr.Mutant SPTLC1 dominantly \ninhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.Hum. \nMolec. Genet. 14: 3507-3521, 2005.\n3. Verhoeven, K., Coen, K., De Vriendt, E., Jacobs, A., Van Gerwen, V., Smouts, I., Pou-Serradell, A., \nMartin, J.-J., Timmerman, V., De Jonghe, P.SPTLC1 mutation in twin sisters with hereditary sensory \nneuropathy type I.Neurology 62: 1001-1002, 2004.

Swiss Prot

O15269

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence in the middle region\nof human SPTLC1.

Scientific Background

SPTLC1(Serine palmitoyltransferase, long chain base subunit 1), also known as SPT1, LCB1, is a \nprotein which in humans is encoded by the SPTLC1 gene. Dawkins et al. (2001)noted that the SPTLC1 \ngene maps to chromosome 9q22.1-q22.3. Serine palmitoyltransferase, which consists of two different \nsubunits, is the initial enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl CoA to \n3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain \nbase subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with \nhereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have \nbeen identified.

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