Quick Search
Products Polyclonal Anti-SSTR2
| Catalogue number: | PA1694 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | SSTR2 |
| Swiss prot: | P30874 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | SSTR2 (Somatostatin receptor type 2) is a protein that in humans is encoded by the SSTR2 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Stable SSTR2 transfection of human pancreatic cells, which do not endogenously express SSTR2, inhibits cell proliferation, tumorigenicity, and metastasis. These effects occur as a consequence of an autocrine SSTR2-dependent loop, whereby SSTR2 induces expression of its own ligand, somatostatin.SSTR2 mRNA was variably expressed in all neuroblastoma tumors with a relevant reduction in the more advanced stage. |
| References: | 1.Buscail, L., Saint-Laurent, N., Chastre, E., Vaillant, J. C., Gespach, C., Capella, G., Kalthoff, H., Lluis, F., Vaysse, N., Susini, C.Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer.Cancer Res. 56: 1823-1827, 1996. 2.Filopanti, M., Ronchi, C., Ballare, E., Bondioni, S., Lania, A. G., Losa, M., Gelmini, S., Peri, A., Orlando, C., Beck-Peccoz, P., Spada, A.Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly.J. Clin. Endocr. Metab. 90: 4824-4828, 2005. 3.Guillermet, J., Saint-Laurent, N., Rochaix, P., Cuvillier, O., Levade, T., Schally, A. V., Pradayrol, L., Buscail, L., Susini, C., Bousquet, C.Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis.Proc. Nat. Acad. Sci. 100: 155-160, 2003. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human SSTR2, identical to the related rat and mouse sequences. |
Get the Best Promotions
