Polyclonal Anti-Stra8

Rabbit IgG polyclonal antibody for Stimulated by retinoic acid gene 8 protein homolog (STRA8) detection. Tested with WB in Human. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1685

Size

100ug/vial

Applications

WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

STRA8

References

1.Anderson, E. L., Baltus, A. E., Roepers-Gajadien, H. L., Hassold, T. J., de Rooij, D. G., van Pelt, A. M. M., Page, D. C.Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice.Proc. Nat. Acad. Sci. 105: 14976-14980, 2008.\n2. Miyamoto, T., Sengoku, K., Takuma, N., Hasuike, S., Hayashi, H., Yamauchi, T., Yamashita, T., Ishikawa, M.Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8.J. Assisted Reprod. Genet. 19: 531-535, 2002.\n

Swiss Prot

Q7Z7C7

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human Stra8.\n\n

Scientific Background

Stra8, stimulated by retinoic acid 8, is expressed in embryonic ovaries just before meiotic initiation, whereas in testis it is expressed after birth. The STRA8 gene contains 9 exons. And this gene is mapped to chromosome 7q31. Retinoic acid (RA) signaling was required for Stra8 expression, and therefore initiation of meiosis, in embryonic mouse ovaries. RA was sufficient to induce Stra8 expression in embryonic testis. Cyp26-mediated RA metabolism was responsible for delaying Stra8 expression in embryonic testis. Since RA signaling regulated Stra8 expression in both embryonic ovaries and adult testis, it was said this portion of the meiotic initiation pathway may be identical in both sexes.