| Catalogue number: |
PA1078-1 |
| Price: |
$200.00 |
| Reactivities: |
Human |
| Applications: |
ELISA, Western Blot |
| Size: |
100?g/vial |
| Gene: |
TIMP4 |
| Swiss prot: |
Q99727 |
| Form: |
lyophilized |
| Format: |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: |
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: |
The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA.The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. Expressed TIMP4 inhibits MMPs in vitro. TIMP4 gene is mapped to chromosome 3p25. TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2. |
| References: |
1. Olson, T. M; Hirohata, S.; Ye, J.; Leco, K.; Seldin, M. F.; Apte, S. S. : Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 gene to human chromosome 3p25 and mouse chromosome 6, respectively. Genomics 51: 148-151, 1998.
2. Bigg, H. F.; Shi, Y. E.; Liu, Y. E.; Steffensen, B.; Overall, C. M. : Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. J. Biol. Chem. 272: 15496-15500, 1997.
|
| Additional info: |
A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP4. |
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