Polyclonal Anti-TXNRD2

Rabbit IgG polyclonal antibody for Thioredoxin reductase 2, mitochondrial (TXNRD2) detection. Tested with WB, IHC-P in Human;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1903

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

TXNRD2

References

1. Gasdaska, P. Y., Berggren, M. M., Berry, M. J., Powis, G.Cloning, sequencing, and functional expression of a novel human thioredoxin reductase.FEBS Lett. 442: 105-111, 1999.\n2. Miranda-Vizuete, A., Damdimopoulos, A. E., Pedrajas, J. R., Gustafsson, J.-A., Spyrou, G.Human mitochondrial thioredoxin reductase: cDNA cloning, expression, and genomic organization.Europ. J. Biochem. 261: 405-412, 1999.\n3. Sun, Q.-A., Wu, Y., Zappacosta, F., Jeang, K.-T., Lee, B. J., Hatfield, D. L., Gladyshev, V. N.Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.J. Biol. Chem. 274: 24522-24530, 1999.\n

Swiss Prot

Q9NNW7

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human TXNRD2, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.

Scientific Background

TXNRD2 (Thioredoxin reductase 2), also known as TRXR2, TR3, SELZ, or TR-BETA, Thioredoxin reductases, are selenocysteine (sec)-containing flavoenzymes that maintain thioredoxins, small proteins that catalyze redox reactions, in the reduced state using the reducing power of NADPH. By STS analysis and genomic sequence analysis, respectively, Miranda-Vizuete et al. (1999) and Sun et al. (1999) mapped the TXNRD2 gene to chromosome 22q11.2. Miranda-Vizuete et al. (1999) mapped the mouse gene to chromosome 16. Gasdaska et al. (1999) showed that TXNRD2 was a thioredoxin reductase that could directly reduce proteins such as insulin.