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Products Polyclonal Anti-Vitronectin/VTN
| Catalogue number: | PA1799 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | VTN |
| Swiss prot: | P04004 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Vitronectin (VTN)also known as complement S-protein, serum spreading factor and somatomedin B is a protein that in humans is encoded by the VTN gene. The protein encoded by this gene is a member of the pexin family. Vitronectin is an abundant glycoprotein found in serum and the extracellular matrix and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. Vitronectin is a 75 kDa glycoprotein, consisting of 459 amino acid residues. By use of high resolution fluorescence in situ hybridization (FISH), Fink et al. (1992) mapped the VTN gene to 17q11. The localization was confirmed by cohybridization with a centromere-specific alphoid probe. About one-third of the protein's molecular mass is composed of carbohydrates. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved in hemostasis and tumor malignancy. |
| References: | 1. Fink, T. M., Jenne, D. E., Lichter, P.The human vitronectin (complement S-protein) gene maps to the centromeric region of 17q.Hum. Genet. 88: 569-572, 1992. 2. Kubota, K., Katayama, S., Matsuda, M., Hayashi, M.Three types of vitronectin in human blood.Cell Struct. Funct. 13: 123-128, 1988. 3. Preissner, K. T., Heimburger, N., Anders, E., Muller-Berghaus, G.Physicochemical, immunological and functional comparison of human S-protein and vitronectin: evidence for the identity of both plasma proteins.Biochem. Biophys. Res. Commun. 134: 951-956, 1986. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human Vitronectin, identical to the related rat and mouse sequences. |
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