Ponatinib

Cat no: 019859

Supplier: United States Biological

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Ponatinib is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors. Melting Point: As reported Solubility: As reported Method for Determining Identity: Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: As reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive. Store under inert atmosphere. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:

Catalogue number:	019859
Size:	10mg
Form:	As reported
Purity:	~90% by HPLC
Alternative names:	3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide; AP 24534;
References:	Weisberg, E., et al.: Cancer Cell, 7, 129 (2005), Zhou, T., et al.: Chem. Biol. Drug Des., 70, 171 (2007), Quintas-Cardama, A., et al.: Blood, 2009, 113, 1619 (2009),

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Ponatinib

Cat no: 019859

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