PP2 (4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine, AG 1879)

Highly potent and selective Scr family tyrosine kinase inhibitor. Reduces cancer metastasis. Apoptotic. Antitumor compound. RIP2 inhbitor. Blocks TGF-beta-mediated cellular responses. Autophagy modulator.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nWorking aliquots are stable for up to 3 months when stored at -20 degrees C. Stable for at least 2 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

045164

Size

1mg

Purity

>98% (HPLC)

References

Product Reference: \n?Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation: J.H. Hanke, et al.; J. Biol. Chem. 271, 695 (1996)\n?Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis: J.S. Nam, et al.; Clin. Cancer Res. 8, 2430 (2002)\n?Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolopyrimidine (PP2): F. Carlomagno, et al.; J. Clin. Endocrinol. Metab. 88, 1897 (2003)\n?The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003)\n?Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia: M. Lee, et al.; J. Cell Biochem. 93, 629 (2004)\n?The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007)\n?The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors: H. Ungefroren, et al.; Curr. Cancer Drug Targets 11, 524 (2011)\n?Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2: J.H. Ahn & M. Lee; Cancer Lett. (Epub ahead of print) (2011)\n?

Alternative Names

4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine, AG 1879