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PR48 (E394) pAb

PR48 (E394) pAb

Cat no: BS3395

Supplier: Bioworld Technology, Inc.
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The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions. The protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. PR48 is a 48 kDa regulatory subunit of protein phosphatase 2A (PP2A). PP2A activity is required for the initiation of DNA replication in yeast, viral, and vertebrate systems. PR48 localizes to the nucleus and binds specifically to Cdc6, a highly conserved protein which is required for the formation of prereplicative complexes. PR48 is considered to be involved in the dephosphorylation of Cdc6 by PP2A, a process important to the control of DNA replication in mammalian cell.
Catalogue number: BS3395
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q9Y5P8
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 370-412 of Human PR48.
Species: PR48 (E394) pAb detects endogenous levels of PR48 protein.
Molecular weight: ~ 70 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta; Protein phosphatase 2A 48 kDa regulatory subunit; PP2A; subunit B; PR48 isoform; PPP2R3B; PPP2R3L; NY-REN-8; PPP2R3LY
Additional info: For research use only, not for use in diagnostic procedure.

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