Home  >  Products  >  PRDX2 (Peroxiredoxin 2, Prx2, Peroxiredoxin-2, Natural Killer Cell-enhancing Factor B, NKEF-B, PRP, Thiol-specific Antioxidant Protein, TSA, Thioredoxin Peroxidase 1, Thioredoxin-dependent Peroxide Reductase 1, NKEFB, TDPX1)
PRDX2 (Peroxiredoxin 2, Prx2, Peroxiredoxin-2, Natural Killer Cell-enhancing Factor B, NKEF-B, PRP, Thiol-specific Antioxidant Protein, TSA, Thioredoxin Peroxidase 1, Thioredoxin-dependent Peroxide Reductase 1, NKEFB, TDPX1)

PRDX2 (Peroxiredoxin 2, Prx2, Peroxiredoxin-2, Natural Killer Cell-enhancing Factor B, NKEF-B, PRP, Thiol-specific Antioxidant Protein, TSA, Thioredoxin Peroxidase 1, Thioredoxin-dependent Peroxide Reductase 1, NKEFB, TDPX1)

Cat no: P3352-12J

Supplier: United States Biological
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Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the aa sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30kD in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: HeLa Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P3352-12J
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG2b,k
Purity: Ascites
References: 1. Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40. 2. Rhee Sue Goo, et al (2001) IUBMB life 52:35-41. 3. Min Hee Choi, et al (2005) Nature letters 435(19):347-353.
Additional info: Recognizes human Peroxiredoxin 2. Species Crossreactivity: mouse and rat.

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