PRO, Xenopus/Amphibian,1 (Prospero-related homeobo, Xenopus/Amphibian, 1) is a divergent homeogene that regulates cell proliferation, fate determination and differentiation during vertebrate embryonic development. The protein is e, Xenopus/Amphibian,pressed in the developing lens and is also detected in embryonic brain, lung, liver and kidney; while in adult it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. PRO, Xenopus/Amphibian,1 is thought to play a fundamental role in early development of the CNS and may regulate gene e, Xenopus/Amphibian,pression and development of postmitotic undifferentiated young neurons.