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Prodigiosin

Cat no: P9005-85

Prodigiosin

Prodigiosin is an intensely red pyrrole pigment produced by several bacteria, most notably, Serratia marcescens. Prodigiosin has a broad biological profile with activity against fungi, tumor cell lines and malaria. It was shown to be an immunosuppressant in 2007. The mode of action of prodigiosin has recently received considerable attention as an inducer of apoptosis in human primary cancer cells via caspase activation. Prodigiosin also acts as an inducer of p21WAF1/CIP1 expression via transforming growth factor-B receptor pathway, and of NAG-1activation by acting on glycogen synthase kinase-3B. \n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility \n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9005-85

Size

500ug

Form

Supplied as a dark red solid.

Purity

~95%

References

1. Seeing red: The story of prodigiosin. Bennett J.W. & Bentley R., Adv. Appl. Microbiol. 2000, 47, 1. 2. Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. Campas C. et al., Leukemia 2003, 17, 746. 3. Prodigiosin: a novel family of immunosuppressants with anti-cancer activity. Pandey R. et al., Indian J. Biochem. Biophys. 2007, 44, 295. 4. The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor- beta receptor pathway. Soto-Cerrato V. et al., Biochem Pharmacol. 2007, 74, 1340. 5. Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells. Soto-Cerrato V. et al., Mol. Cancer Ther. 2007, 6, 362. 6. Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell line. Monge M. et al., Invest. New Drugs 2007, 25, 21.

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