Progesterone Receptor (Ser190) Antibody

Cat no: 252575

Supplier: ABBIOTEC

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Description
Additional Information

There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell conte, Xenopus/Amphibian,ts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.

Catalogue number:	252575
Reactivities:	Human
Applications:	Immunohistochemistry
Size:	0.1 ml
Accession:	P06401
Antigen:	KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser190 of human progesterone receptor.
Format:	Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
P type:	Mouse Monoclonal Antibody,Porcinehosphospecific Antibody
Isotype:	Mouse IgG1
Clonality:	1154
Additional info:	Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C3