Progranulin (Proepithelin, PEPI, PC Cell-derived Growth Factor)

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.\n\nApplications:\nSuitable for use in ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot\n\nRecommended Dilution:\nOptimal dilutions to be determined by researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

045169

Size

100ug

Applications

ELISA, IHC, IP, WB

Hosts

Mouse

Form

Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1,k

References

Product Reference: \n?Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish: Y.H. Li, et al.; JBC 285, 41001 (2010)\n?

Additional Info

Recognizes human progranulin. Detects a band of ~90kD by Western blot.

Alternative Names

Proepithelin, PEPI, PC Cell-derived Growth Factor