Proopiomelanocortin (POMC, Adrenocorticotropin, beta Lipotropin, alpha (beta) Melanocyte Stimulating Hormone, ACTH, CLIP, Corticotropin-lipotropin precursor, LPH, MSH, NPP, POC, Pro-opiomelanocortin)

Supplier:

United States Biological

Cat no: P9025P

Proopiomelanocortin (POMC, Adrenocorticotropin, beta Lipotropin, alpha (beta) Melanocyte Stimulating Hormone, ACTH, CLIP, Corticotropin-lipotropin precursor, LPH, MSH, NPP, POC, Pro-opiomelanocortin)

Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. It is synthesized by corticotrope cells of the anterior pituitary gland, melanotrope cells of the intermediate lobe of the pituitary gland, about 3000 neurons in the arcuate nucleus of the hypothalamus, and smaller populations of neurons in the dorsomedial hypothalamus and brainstem.\nThe large molecule of POMC is the source of several important biologically active substances. POMC can be cleaved enzymatically into the following peptides:\nadrenocorticotrophic hormone (ACTH) and gamma LPH in the anterior pituitary gland\nCLIP, gamma LPH, gamma MSH and beta-endorphin in the intermediate lobe gamma-MSH\nmet-enkephalin\nEach of these peptides is packaged in large dense-core vesicles that are released from the cells by exocytosis in response to appropriate stimulation. gamma MSH produced by neurons in the arcuate nucleus has important roles in the regulation of appetite and sexual behavior, while a-MSH secreted from the intermediate lobe of the pituitary regulates the production of melanin. ACTH is a peptide hormone that regulates the secretion of glucocorticoids from the adrenal cortex.\nbeta-endorphin and met-enkephalin are endogenous opioid peptides with widespread actions in the brain.\n\nSynthetic peptide to porcine POMC Precursor (aa27

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SPECIFICATIONS

Catalog Number

P9025P

Size

1mg

References

Schally, A.V., et al., PNAS 88, 3540 (1991)

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

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