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Protein Kinase Inhibitor (PKI, SB203580, \n4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-\n5-(4-pyridyl)1H-imidazole)

Cat no: P9104-76

Protein Kinase Inhibitor (PKI, SB203580, \n4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-\n5-(4-pyridyl)1H-imidazole)

The Protein Kinase Inhibitor is a selective inhibitor of p38 mitogen-activated protein (MAP) kinase, which acts by competitively inhibiting ATP binding. This compound inhibits p38 MAPK stimulation of MAPKAPK2 (IC50 = 70nM) and is a useful tool for assessing the physiological roles of p38.\n\nBiological Activity: \nKi = 21nM, determined by measuring competitive inhibition of ATP binding.\n\nSolubility:\nSoluble in DMSO at a concentration of 50mg/ml.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

P9104-76

Size

1mg

Form

Supplied as a lyophilized powder. This product is not sterile.

Purity

~98% (TLC)

References

US Biological application reference:

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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