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Protein Kinase Inhibitor (PKI, SB203580, 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)- 5-(4-pyridyl)1H-imidazole)

Cat no: P9104-76


Supplier: United States Biological
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The Protein Kinase Inhibitor is a selective inhibitor of p38 mitogen-activated protein (MAP) kinase, which acts by competitively inhibiting ATP binding. This compound inhibits p38 MAPK stimulation of MAPKAPK2 (IC50 = 70nM) and is a useful tool for assessing the physiological roles of p38. Biological Activity: Ki = 21nM, determined by measuring competitive inhibition of ATP binding. Solubility: Soluble in DMSO at a concentration of 50mg/ml. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: P9104-76
Size: 1mg
Form: Supplied as a lyophilized powder. This product is not sterile.
Purity: ~98% (TLC)
References: US Biological application reference:

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