Small ubiquitin-like modifier (SUMO) is a post-translational modification of proteins that refers to the covalent attachment of a small ubiquitin-associated modifier to a protein. Unlike ubiquitination, which targets proteins for degradation, sumoylation modulates protein function across several cellular processes including nucleocytoplasmic transport, transcription regulation, apoptosis, protein stability, stress response, and cell cycle progression.
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