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Protein Synthesis Initiation Factor 4E [pS209], Pos/Neg Control Peptides (eIF 4E, Eukaryotic Translation Initiation Factor )

Cat no: P9108-50C

Protein Synthesis Initiation Factor 4E [pS209], Pos/Neg Control Peptides (eIF 4E, Eukaryotic Translation Initiation Factor )

Eukaryotic initiation factor 4E (eIF4E) binds to the mRNA cap structure, thereby mediating the initiation of translation (1,2). eIF4E interacts with eIF4G, which serves as a scaffold protein for the assembly of eIF4E and eIF4A to form the eIF4F complex (2). Upon activation by mitogenic and/or stress stimuli mediated by Erk and p38 MAPK, Mnk1 has been shown to phosphorylate eIF4E at Ser209 in vivo (3,4). Two Erk and p38 MAPK phosphorylation sites have been identified in mouse Mnk1, Thr197 and Thr202, which are essential for Mnk1 kinase activity (3). The C-terminal region of eIF4G also contains serum-stimulated phosphorylation sites, including Ser1108, Ser1148 and Ser1192 (5). It is known that their phosphorylation is blocked by the PI3 kinase inhibitor LY294002 and by the FRAP/mTOR inhibitor rapamycin.\n\nPeptide Content: 80

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SPECIFICATIONS

Catalog Number

P9108-50C

Size

1mg

Form

Supplied as a lyophilized powder.

Purity

~90% by HPLC and MS analysis

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